GC00245

Accession No

Strain Name

Wistar.Tspan7 (tm)

Status

Freezed embryo

Gene/full name

Tspan7/ tetraspanin 7

Gene ID

7102

Background

Wistar

Type

Knockout

Donor

Lianfeng Zhang, Li Zhang, Wei Dong

Disease & Phenotype

Autism spectrum disorder

Construction Description

We used the CRISPR/Cas9 technique to knock out the Tspan7 ortholog in rats and acquired two Tspan7−/y founders.

Genotyping Protocols

Mating System

Heterozygote x Wistar

Reference

Pang S, Luo Z, Dong W, Gao S, Chen W, Liu N, Zhang X, Gao X, Li J, Gao K, Shi X, Guan F, Zhang L, Zhang L. Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats. Life Sci Alliance. 2022 Dec 20;6(3):e202201616.