GC00246

Accession No

Strain Name

SD. Isca1(tm-NeuN-cre)

Status

Freezed embryo

Gene/full name

Isca1/ iron-sulfur cluster assembly 1

Gene ID

81689

Background

Sprague Dawley

Type

Neuron-specific Knock out

Donor

Lianfeng Zhang, Li Zhang, Wei Dong

Disease & Phenotype

Multiple mitochondrial dysfunction syndromes (MMDS)

Construction Description

We generated neuron-specific Isca1 knockout rat Isca1flox/flox and NeuN-Cre rats using CRISPR-Cas9 technology.

Genotyping Protocols

Mating System

Isca1flox/flox x NeuN-Cre

Reference

Sheng H, Lu D, Qi X, Ling Y, Li J, Zhang X, Dong W, Chen W, Gao S, Gao X, Zhang L, Zhang L. A neuron-specific Isca1 knockout rat developments multiple mitochondrial dysfunction syndromes. Animal Model Exp Med. 2023 Apr;6(2):155-167.